Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy.

@article{Youn2006ZonalVI,
  title={Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy.},
  author={Inchan Youn and Jae Bong Choi and Li Cao and Lori A. Setton and Farshid Guilak},
  journal={Osteoarthritis and cartilage},
  year={2006},
  volume={14 9},
  pages={889-97}
}
OBJECTIVE Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM), which together with the enclosed cell(s) are termed the "chondron". Although the precise function of this tissue region is unknown, previous studies provide indirect evidence that the PCM plays an important role in governing the local mechanical environment of chondrocytes. In particular, theoretical models of the chondron under mechanical loading suggest that the shape, size, and biomechanical… CONTINUE READING

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