Zonal redox changes as a cause of selective perivenular hepatotoxicity of alcohol.

Alcohol-induced lesions predominate in perivenular zones of the liver. To test the hypothesis that ethanol aggravates hypoxia in this zone by stimulating oxygen consumption, we measured hepatic venous pO2 after ethanol-administration to both alcohol-fed baboons (with perivenular lesions) and their controls, and found no changes: the stimulation of oxygen… CONTINUE READING