• Corpus ID: 25633915

Zonal changes in renal structure and phospholipid metabolism in potassium-deficient rats.

@article{Toback1976ZonalCI,
  title={Zonal changes in renal structure and phospholipid metabolism in potassium-deficient rats.},
  author={F. Gary Toback and Nelson G. Ord{\'o}{\~n}ez and Simon Bortz and Benjamin H. Spargo},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1976},
  volume={34 2},
  pages={
          115-24
        }
}
  • F. Toback, N. Ordóñez, B. Spargo
  • Published 1 February 1976
  • Biology, Medicine
  • Laboratory investigation; a journal of technical methods and pathology
Morphologic alterations and membrane metabolism were studied in the kidneys of rats fed a low potassium diet. Transmission and scanning electron microscopy following perfusion-fixation of kidneys revealed that the earliest morphologic change occurs in cells of the papillary tip in which multivesicular bodies, a specific type to lysosome, appear after 1 day. Increased depletion leads to extension of the lesion to all cells of the papilla. After 1 week, a narrow band of hyperplasia in the inner… 
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