Zona glomerulosa function after life-long suppression in two siblings with the hypertensive virilizing form of congenital adrenal hyperplasia.

@article{Portales1988ZonaGF,
  title={Zona glomerulosa function after life-long suppression in two siblings with the hypertensive virilizing form of congenital adrenal hyperplasia.},
  author={J A Rodr{\'i}guez Portales and Eugenio Arteaga and J M L{\'o}pez Moreno and Edward G. Biglieri},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1988},
  volume={66 2},
  pages={349-54}
}
The function of the adrenal zona glomerulosa was studied in two pubertal siblings with the hypertensive virilizing form of congenital adrenal hyperplasia who had never been treated. Initially, their plasma 11-deoxycortisol and 11-deoxycorticosterone (DOC) levels were very high, PRA was suppressed, and plasma aldosterone and 18-hydroxycorticosterone (18-OHB) were undetectable. To selectively study zona glomerulosa function, the patients and five normal subjects were given dexamethasone (2 mg/day… CONTINUE READING