Zolpidem use and risk of fractures: a systematic review and meta-analysis

@article{Park2016ZolpidemUA,
  title={Zolpidem use and risk of fractures: a systematic review and meta-analysis},
  author={S. M. Park and J. Ryu and D. R. Lee and D. Shin and J. Yun and J. Lee},
  journal={Osteoporosis International},
  year={2016},
  volume={27},
  pages={2935-2944}
}
SummaryZolpidem is a representative of non-benzodiazepine hypnotics. Recent epidemiologic studies have reported increased fracture risk in patients taking zolpidem, but the results have been inconsistent. The present meta-analysis shows that the use of zolpidem is associated with an increased risk of fractures.PurposePrevious studies have reported inconsistent findings regarding the association between the use of zolpidem and the risk of fractures. We performed a systematic literature review… Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Association between use of benzodiazepines and risk of fractures: a meta-analysis
TLDR
The results from the present meta-analysis show that BZD use is associated with a moderate and clinically significant increase in the risk of fractures, and clinicians should consider fracture risk when prescribing BZDs among the elderly population. Expand
Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case–control studies
TLDR
The SSRIs may exert an increased risk of fracture independent of depression and bone mineral density and the overall association between SSRI use and fracture risk was weaker. Expand
Fractures in users of antidepressants and anxiolytics and sedatives: effects of age and dose
TLDR
Increasing age was associated with more fractures in users of selective serotonin reuptake inhibitors and tricyclic antidepressants, whereas for anxiolytics and sedatives, more fractures were seen among the younger users, and a hospital diagnosis of depression or manic depression was not a risk factor for fractures. Expand
Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study
TLDR
It was found that patients prescribed with Zolpidem were at a higher risk for a wide range of injuries. Expand
Anxiolytics and Sedatives and Risk of Fractures: Effects of Half-life
TLDR
It is concluded that anxiolytics, sedatives, and hypnotics are associated with a limited increase in the risk of fractures, and for most drugs a dose-response relationship was present, and drugs with a half-life longer than 24 h tended to be associated withA dose-dependent risk of falls leading to fractures. Expand
Benzodiazepine and risk of hip fractures in older people: a nested case-control study in Taiwan.
TLDR
Benzodiazepine exposure in the elderly increases the risk of hip fractures, and Clinicians should prescribe benzodiazepines judiciously with the elderly to minimize drug-related hip fractures. Expand
Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients
TLDR
Zolpidem could increase the risk of fracture in elderly insomnia patients and should be prescribed carefully and the elderly should be provided with sufficient patient education. Expand
Risk of hip fracture among older people using anxiolytic and hypnotic drugs: a nationwide prospective cohort study
TLDR
Older people had an increased risk of hip fracture during anxiolytic or hypnotic drug use, including short-acting benzodiazepine anxio-lytics and z-hypnotics that were previously considered less harmful; cautious prescribing is therefore needed. Expand
Retrospective population cohort study on hip fracture risk associated with zolpidem medication.
TLDR
The hip fracture risk of zolpidem users is higher than that of nonusers and Fracture prevention awareness should be disseminated to the users. Expand
Benzodiazepines and hip fractures in elderly people: case-control study
TLDR
Except for lorazepam, the presence of benzodiazepines in plasma was not associated with an increased risk of hip fracture, and the method used to ascertain exposure could influence the results of case-control studies. Expand
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