Zolpidem for the Treatment of Neurologic Disorders: A Systematic Review

@article{Bomalaski2017ZolpidemFT,
  title={Zolpidem for the Treatment of Neurologic Disorders: A Systematic Review},
  author={Martin N Bomalaski and E. Claflin and W. Townsend and M. Peterson},
  journal={JAMA Neurology},
  year={2017},
  volume={74},
  pages={1130–1139}
}
Importance Given its selective action on the &ohgr;1 subtype of the &ggr;-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015. Searched databases… Expand
Zolpidem for the Treatment of Dystonia
TLDR
While the current available literature suggests that zolpidem may be an effective pharmacologic option for treating dystonia, however the quality of evidence remains limited, larger sample size, methodological consistency, and randomized controlled trials with long-term patient follow-ups are necessary to come up with definitive conclusion. Expand
Zolpidem stimulant effect: Induced mania case report and systematic review of cases
TLDR
A systematic review of the zolpidem-induced stimulation, euphoric or manic effects found that 89.4% of cases were euphoric and 15.7% had drug-induced mania with delusions, which should be contraindicated for populations with identified risk factors. Expand
A Retrospective Analysis on Clinical Practice-Based Approaches Using Zolpidem and Lorazepam in Disorders of Consciousness
TLDR
The results suggested the etiology of DoC, considering traumatic vs. anoxic injuries, may serve in guiding the clinical application of these medications in the treatment of doC and in future prospective studies. Expand
The Effect of Zolpidem on Language Function of Patients With Nonfluent Variant of Frontotemporal Dementia: A Pilot Study
TLDR
The study showed that zolpidem did not affect the improvement of language function in patients with nfv-PPA, and traditional language structures do not seem to be sensitive to the modulatory effects of zolPidem. Expand
Use of Zolpidem in Disorders of Consciousness Secondary to Autoimmune Encephalitis
TLDR
Questions are raised about the effect of Zolpidem as an adjunct to immunotherapy in patients with anti NMDA receptor encephalitis, which leads us to question theeffect of ZOLpidem in Patients with disorders of consciousness. Expand
Psychedelics for Brain Injury: A Mini-Review
Objective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalizationExpand
Polypharmacy and Rational Prescribing: Changing the Culture of Medicine One Patient at a Time
TLDR
Physiatrists are well positioned to have a positive impact on rational prescribing and polypharmacy given their emphasis on function, familiarity with non-medication treatment modalities, and an embrace of a biopsychosocial orientation. Expand
Neuroinflammation is a putative target for the prevention and treatment of perioperative neurocognitive disorders.
TLDR
This review considers how to prepare for and manage the vulnerable elderly surgical patient through the entire spectrum, from preoperative assessment to postoperative period, fromPreclinical and clinical reports were considered. Expand
On the pathophysiology and treatment of akinetic mutism
TLDR
Evidence from lesion studies and neurophysiological evidence in animals, imaging studies in humans, and clinical investigations in patients with AM are combined to form an integrative theory of its pathophysiology to form a comprehensive overview for use in clinical practice. Expand
Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
TLDR
It is reported that zolpidem induces a change in MEG resting power and functional connectivity in the patient, and MEG is an informative and sensitive tool to detect changes in brain activity for TBI. Expand
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Efficacy of Zolpidem for Dystonia: A Study Among Different Subtypes
TLDR
Zolpidem, an imidazopyridine agonist with a high affinity on benzodiazepine subtype receptor BZ1 (ω1), was found to improve clinical symptoms of dySTONia in a limited number of case reports and may be a therapeutic option for generalized dystonia, Meige syndrome, and hand dystonIA including musician’s. Expand
Beneficial Effect of Zolpidem for Dementia
TLDR
The temporal relationship between zolpidem intake (consistent with its pharmacokinetic properties) and improvement in cognitive function, with repetition at each dose, indicated a causal relationship with zolPidem. Expand
Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy
TLDR
A 73-year-old woman with a six-year history of PSP, who, upon administration of a single 12.5 mg dose of sustained-release zolpidem, exhibited marked enhancements in speech, facial expressions, and fine motor skills for five hours, was observed. Expand
Zolpidem for Antipsychotic-Induced Parkinsonism
TLDR
Zolpidem was reinstated at 5 mg four × daily, and the patient's tremors have been stable for two years, and further investigation is needed to study the use of nontraditional medications in patients requiring antipsychotic medications who have refractory parkinsonian symptoms. Expand
Incidence of Clinically Significant Responses to Zolpidem Among Patients with Disorders of Consciousness: A Preliminary Placebo Controlled Trial
  • J. Whyte, R. Myers
  • Medicine
  • American journal of physical medicine & rehabilitation
  • 2009
TLDR
It is confirmed that clinically significant responses to zolpidem among individuals with disorders of consciousness do occur in a minority of patients and can be replicated, and failure to find a trend toward improved performance on zolPidem among nonresponders suggests a bimodal rather than a graded response to the drug. Expand
Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics.
TLDR
It would appear that zolpidem does not offer a beneficial effect in this setting, and was associated with a tendency towards reduced responsiveness in patients with persistent vegetative states. Expand
Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
TLDR
The present open-label study failed to show any clinically significant improvement in the effects of zolpidem in chronic disorders of consciousness in any of the 60 studied chronic DOC patients. Expand
Zolpidem in a minimally conscious state
TLDR
This study treated a 44 year old male with MCS some 4 years after his traumatic brain injury with zolpidem for 1 week on and 1 week off treatment and found that his scores were no better on zolPidem and in some cases were worse on treatment. Expand
Zolpidem and its effects on hypoxic encephalopathy
TLDR
Global understanding of neurological disease will be enhanced, local communities will benefit from education that leads to primary prevention, and new treatments will become available for those who have succumbed to the neglected neurological conditions of the Third World. Expand
Zolpidem dramatically improved motor and speech function in a patient with central pontine myelinolysis
TLDR
A 51-year-old alcoholic female with a history of alcoholism, who gained dramatic improvement in motor and speech function after treatment with zolpidem, is reported, which is compatible with a diagnosis of CPM. Expand
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