Corpus ID: 29816915

Zolpidem at supratherapeutic doses can cause drug abuse, dependence and withdrawal seizure.

@article{Sethi2005ZolpidemAS,
  title={Zolpidem at supratherapeutic doses can cause drug abuse, dependence and withdrawal seizure.},
  author={P. Sethi and D. Khandelwal},
  journal={The Journal of the Association of Physicians of India},
  year={2005},
  volume={53},
  pages={
          139-40
        }
}
Zolpidem is a non-benzodiazepine hypnotic drug, acts selectively through omega 1 receptors of GABAA. It is thought to be safer than benzodiazepines but we report a case of zolpidem drug abuse, dependence and withdrawal seizure. 
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References

SHOWING 1-7 OF 7 REFERENCES
Abuse, dependence, and epileptic seizures after zolpidem withdrawal: review and case report.
TLDR
It is stressed that the subjective effects of zolpidem are comparable to those of other BZs, and that abuse, dependence, and withdrawal seizures cannot be avoided simply shifting the regimen of a BZ abuser to zolPidem. Expand
[Dependence on zolpidem: a report of two cases].
TLDR
The Authors report 2 cases of addiction to high dose of zolpidem and compare them with others described in the literature, concluding that drug addicts are more likely to become dependent on zolPidem. Expand
[Epileptic seizures as a sign of abstinence from chronic consumption of zolpidem].
TLDR
It is shown that in spite of the descriptions in the medical literature, complications may follow long term use of zolpidem, and it is considered that its indiscriminate use should be modified. Expand
Zolpidem-related epileptic seizures: a case report
TLDR
A case of seizures that developed in a female patient taking increasing doses of zolpidem up to 600 mg/d for many months appears as a serious diagnostic problem, since no one in the patient's family was aware of the patient’s abuse of zOLpidem. Expand
Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.
TLDR
Neither spontaneous nor flumazenil-induced precipitated withdrawal was observed in zolpidem-treated mice, and there was no change in its ability to produce sedative and anticonvulsant effects. Expand