Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers

@inproceedings{Almubarak2011ZoledronicAD,
  title={Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers},
  author={Hussain Almubarak and Antonia J. Jones and Risa Chaisuparat and Ming Zhang and Timothy Francis Meiller and Mark A. Scheper},
  booktitle={Journal of carcinogenesis},
  year={2011}
}
BACKGROUND Bisphosphonates (BPs) were designed for the prevention of skeletal-related events secondary to bone metastases. The purpose of this study was to show that zoledronic acid (ZA) directly eradicates highly tumorigenic and potentially metastatic cancer cells. MATERIALS AND METHODS Human prostate and breast highly tumorigenic (PC3, MCF 7) and low- or non-tumorigenic (LNCaP, MCF 10a) cell lines, respectively, were exposed to different concentrations of ZA (0-10 μM). Reverse transcriptase… CONTINUE READING
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