Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice

@article{Kobayashi2009ZoledronicAD,
  title={Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice},
  author={Yasuyoshi Kobayashi and Toru Hiraga and Akimi Ueda and Liyang Wang and Michiyo Matsumoto-Nakano and Kenji Hata and Hirofumi Yatani and Toshiyuki Yoneda},
  journal={Journal of Bone and Mineral Metabolism},
  year={2009},
  volume={28},
  pages={165-175}
}
Nitrogen-containing bisphosphonates such as zoledronic acid (ZOL) and pamidronate have been widely and successfully used for the treatment of cancer patients with bone metastases and/or hypercalcemia. Accumulating recent reports have shown that cancer patients who have received these bisphosphonates occasionally manifest bisphosphonate-related osteonecrosis of the jaw (BRONJ) following dental treatments, including tooth extraction. However, little is known about the pathogenesis of BRONJ to… CONTINUE READING