Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways.

@article{Hasmim2007ZoledronateIE,
  title={Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways.},
  author={Meriem Hasmim and Gr{\'e}gory Bieler and Curzio R{\"u}egg},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2007},
  volume={5 1},
  pages={166-73}
}
BACKGROUND Recent evidence indicates that zoledronate, a nitrogen-containing bisphosphonate used to treat conditions of increased bone resorption, may have anti-angiogenic activity. The endothelial cells signaling events modulated by zoledronate remain largely elusive. OBJECTIVES The aim of this work was to identify signaling events suppressed by zoledronate in endothelial cells and responsible for some of its biological effects. METHODS Human umbilical vein endothelial cells (HUVEC) were… CONTINUE READING