Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study.

@article{Wessel2008ZoledronateSA,
  title={Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study.},
  author={John H Wessel and Thomas Benton Dodson and Athanasios I. Zavras},
  journal={Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons},
  year={2008},
  volume={66 4},
  pages={625-31}
}
PURPOSE Bisphosphonates (BPs) effectively treat metastatic bone disease, hypercalcemia, and osteoporosis. BP exposure, however, may be associated with osteonecrosis of the jaw (ONJ). The aim of the present study was to estimate the magnitude of the association between intravenous (IV) BP exposure and ONJ, and to identify potential confounders. MATERIALS AND METHODS Using a case-control study design, the investigators identified and adjudicated a sample of cases with ONJ and matched them… CONTINUE READING
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