ZnuA and zinc homeostasis in Pseudomonas aeruginosa

  title={ZnuA and zinc homeostasis in Pseudomonas aeruginosa},
  author={Victoria G. Pederick and Bart A. Eijkelkamp and Stephanie L. Begg and Miranda Ween and Lauren J. McAllister and James C Paton and Christopher A McDevitt},
  booktitle={Scientific reports},
Pseudomonas aeruginosa is a ubiquitous environmental bacterium and a clinically significant opportunistic human pathogen. Central to the ability of P. aeruginosa to colonise both environmental and host niches is the acquisition of zinc. Here we show that P. aeruginosa PAO1 acquires zinc via an ATP-binding cassette (ABC) permease in which ZnuA is the high affinity, zinc-specific binding protein. Zinc uptake in Gram-negative organisms predominantly occurs via an ABC permease, and consistent with… CONTINUE READING
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