Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos

@article{Jung2019Znf76IA,
  title={Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos},
  author={Jangham Jung and S. Udhaya Kumar and Issac Choi and Tea-Lin Huh and Myungchull Rhee},
  journal={Animal Cells and Systems},
  year={2019},
  volume={23},
  pages={26 - 31}
}
ABSTRACT ZNF76 is a transcriptional repressor that targets the TATA-binding protein (TBP) and plays an essential role during brain development; however, its function during embryogenesis remains unclear. Here, we report the expression pattern and potential functions of znf76 in zebrafish embryos. Maternal transcripts of znf76 were detected at low levels in embryos at the 1-cell stage, with zygotic transcripts appearing at the sphere stage. At the bud stage, the distribution of znf76 transcripts… Expand
Trim45 is essential to the development of the diencephalon and eye in zebrafish embryos
TLDR
Possible roles of Trim45 in the development of the diencephalon and eye in zebrafish embryos are proposed and its expression patterns and developmental functions are reported. Expand
Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos
TLDR
A signaling network where trim46a contributes to development of the midbrain and MHB via Foxa2, a downstream element of SHH signaling in zebrafish embryogenesis is proposed. Expand
march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos
TLDR
The essential role of March5 in the development of zebrafish embryos is demonstrated and the transcription of march5 was tightly regulated by the transcriptional regulators CHOP, C/EBPα, Staf, Znf143a, andZnf76. Expand
Hunting for the genetic basis of Susac syndrome
Susac syndrome (SuS) is a rare microvasculopathy affecting the brain, the retina, and the inner ear1 whom pathophysiology is not yet fully understood2 even if recent analysis showed vasculitis3 andExpand

References

SHOWING 1-10 OF 30 REFERENCES
Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos
TLDR
It is proposed that Rnf152 is essential for development of the eyes, midbrain and hindbrain, and that Delta-Notch signaling is involved. Expand
Zebrafish pax[b] is involved in the formation of the midbrain–hindbrain boundary
TLDR
It is shown that injection of antibodies raised against the pax[b] protein causes a localized malformation at the mid-brain–hindbrain boundary and downregulation of pax,[b] transcripts in the posterior midbrain and alteration of wnt-1 and eng-2 expression in this area. Expand
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.
TLDR
It is suggested that multiple signaling pathways are independently activated in the mid brain-hindbrain boundary primordium during gastrulation, and that Fgf8 functions later during somitogenesis to polarize the midbrain. Expand
Expression patterns of prune2 is regulated by Notch and retinoic acid signaling pathways in the zebrafish embryogenesis.
TLDR
The expression profiles and transcriptional regulation of prune2 in zebrafish embryos are defined and it is proposed that Prune2 might be a putative regulator for CNS development in zbrafish embryogenesis. Expand
Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis.
TLDR
The characteristic expression pattern of pax[zf-b] in the neural tube suggests an involvement of this gene in the regionalization of the midbrain as well as in the specification of neuronal cell fates at early embryonic stages. Expand
Fgf8 signaling for development of the midbrain and hindbrain
TLDR
How midbrain and hindbrain are specified is reviewed, and Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain, and activates Ras‐ERK pathway to specify hindbrain. Expand
Stages of embryonic development of the zebrafish
TLDR
A series of stages for development of the embryo of the zebrafish, Danio (Brachydanio) rerio is described, providing for flexibility and continued evolution of the staging series as the authors learn more about development in this species. Expand
A regulator of transcriptional elongation controls vertebrate neuronal development
TLDR
The mutant foggy is described, identified in a genetic screen for mutations that affect neuronal development in zebrafish, that displayed a reduction of dopamine- containing neurons and a corresponding surplus of serotonin-containing neurons in the hypothalamus. Expand
Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system
TLDR
The developmental expression and localization of these two multifingered CCHC proteins suggests that each may play a role in the development of neurons and oligodendroglia in the mammalian central nervous system. Expand
Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
TLDR
It is suggested that the Foxi1-Pax8 pathway provides an early `jumpstart' of otic specification that is maintained by the Dlx3b-P Pax2a pathway. Expand
...
1
2
3
...