Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures.

@article{Kim1999Zn2EP,
  title={Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures.},
  author={Eui Yon Kim and Jae Young Koh and Young Hoon Kim and Seonghyang Sohn and Eun-Hye Joe and Byoung Joo Gwag},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 1},
  pages={327-34}
}
Evidence has accumulated that Zn2+ plays a central role in neurodegenerative processes following brain injuries including ischaemia or epilepsy. In the present study, we examined patterns and possible mechanisms of Zn2+ neurotoxicity. Inclusion of 30-300 microM Zn2+ for 30 min caused neuronal necrosis apparent by cell body and mitochondrial swelling in cortical cell cultures. This Zn2+ neurotoxicity was not attenuated by antiapoptosis agents, inhibitors of protein synthesis or caspase. Blockade… CONTINUE READING

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