Zn(II)/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies.

@article{Konidaris2014ZnIIpyridyloximeCA,
  title={Zn(II)/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies.},
  author={Konstantis F. Konidaris and Georgios A. Dalkas and Eugenia Katsoulakou and George N Pairas and Catherine P. Raptopoulou and Fotini N Lamari and Georgios A Spyroulias and Evy Manessi-Zoupa},
  journal={Journal of inorganic biochemistry},
  year={2014},
  volume={134},
  pages={12-9}
}
In order to investigate the ability of metal complexes to act as reactivators of organophosphorus compounds (OP)-inhibited acetylcholinesterase (AChE), we have synthesized and crystallographically characterized three novel mononuclear Zn(II) complexes formulated as [ZnCl2{(4-py)CHNOH}2] (1), [ZnBr2{(4-py)CHNOH}2] (2) and [Zn(O2CMe)2{(4-py)CHNOH}2]∙2MeCN (3∙2MeCN), where (4-py)CHNOH is 4-pyridinealdoxime. Their reactivation potency was tested in vitro with a slight modification of the Ellman's… CONTINUE READING

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