Zn(2+) slows down Ca(V)3.3 gating kinetics: implications for thalamocortical activity.

@article{Cataldi2007Zn2SD,
  title={Zn(2+) slows down Ca(V)3.3 gating kinetics: implications for thalamocortical activity.},
  author={Mauro Cataldi and Vincenzo Lariccia and Viviana Marzaioli and Anna Cavaccini and Giulia Curia and Domenico Viggiano and Lorella Maria Teresa Canzoniero and Gianfranco di Renzo and Massimo Avoli and Lucio Annunziato},
  journal={Journal of neurophysiology},
  year={2007},
  volume={98 4},
  pages={2274-84}
}
We employed whole cell patch-clamp recordings to establish the effect of Zn(2+) on the gating the brain specific, T-type channel isoform Ca(V)3.3 expressed in HEK-293 cells. Zn(2+) (300 microM) modified the gating kinetics of this channel without influencing its steady-state properties. When inward Ca(2+) currents were elicited by step depolarizations at voltages above the threshold for channel opening, current inactivation was significantly slowed down while current activation was moderately… CONTINUE READING

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