Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.

@article{Nishikimi2005Zizimin2AN,
  title={Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.},
  author={Akihiko Nishikimi and Nahum Meller and Natsuko Uekawa and Ken-ichi Isobe and Martin A Schwartz and Mitsuo Maruyama},
  journal={FEBS letters},
  year={2005},
  volume={579 5},
  pages={1039-46}
}
A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related proteins TC10 or TCL. Their tissue distributions are distinct, however, with… CONTINUE READING