Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes

@article{Nishikimi2005Zizimin2AN,
  title={Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes},
  author={Akihiko Nishikimi and Nahum Meller and Natsuko Uekawa and Ken-ichi Isobe and Martin Alexander Schwartz and Mitsuo Maruyama},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42‐related proteins TC10 or TCL. Their tissue distributions are distinct, however, with… 
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The domain structure of Zizimin proteins is discussed from an evolutionary viewpoint and what is currently known about the mammalian ZizIMin proteins to that of related Dock proteins are compared.
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It is demonstrated that the N-terminal half of zizimin1 binds to the GEF domain through three distinct areas, including the CZH1, to inhibit the interaction with Cdc42.
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It is suggested that Zizimin2 is an immune-related and age-regulated guanine nucleotide exchange factor, which facilitates filopodial formation through activation of Cdc42, which results in activation of cell migration.
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TLDR
An overview of the biological and structural characteristics for the various DOCK proteins is provided and how they differ from other RHO GEFs and between DOCK subfamilies is described.
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TLDR
Dock180 and ELMO function together as a bipartite GEF to optimally activate Rac on upstream stimulation to mediate the engulfment of apoptotic cells and cell migration.
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TLDR
Rat monoclonal antibodies against mouse Zizimin2 protein are established and determined their isotypes and further examined capability or availability in immunoblotting, immunoprecipitation, or immunofluorescence microscopy.
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TLDR
This review will summarize the newly accumulated findings concerning the Dock180-related proteins' molecular and cellular functions, emphasizing the roles of these proteins in neuronal cells and glial cells as well as their interactions in the central and peripheral nervous systems.
Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.
TLDR
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