Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes

@article{Nishikimi2005Zizimin2AN,
  title={Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes},
  author={A. Nishikimi and N. Meller and N. Uekawa and K. Isobe and M. Schwartz and M. Maruyama},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
  • A. Nishikimi, N. Meller, +3 authors M. Maruyama
  • Published 2005
  • Biology, Medicine
  • FEBS Letters
  • A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42‐related proteins TC10 or TCL. Their tissue distributions are distinct, however, with… CONTINUE READING
    61 Citations
    CZH proteins: a new family of Rho-GEFs
    • 270
    • PDF
    GEF what? Dock180 and related proteins help Rac to polarize cells in new ways.
    • 321
    Dock180-ELMO cooperation in Rac activation.
    • 77
    Cellular signaling of Dock family proteins in neural function.
    • 73
    Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.
    • 42
    • Highly Influenced

    References

    SHOWING 1-10 OF 33 REFERENCES
    Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins
    • 170
    Lck regulates Vav activation of members of the Rho family of GTPases.
    • 333
    • PDF
    Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity
    • 392
    • Highly Influential
    • PDF
    Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase*
    • 166
    • PDF
    The Dbl family of oncogenes.
    • 504
    GTPases and T cell activation
    • 155
    Rho-family GTPases: it's not only Rac and Rho (and I like it)
    • 597
    • Highly Influential
    • PDF
    Isolation and characterisation of DOCK8, a member of the DOCK180‐related regulators of cell morphology
    • 104