Zirconium, niobium, antimony, vanadium and lead in rats: life term studies.

@article{Schroeder1970ZirconiumNA,
  title={Zirconium, niobium, antimony, vanadium and lead in rats: life term studies.},
  author={Henry Alfred Schroeder and Marian Mitchener and Alexis P. Nason},
  journal={The Journal of nutrition},
  year={1970},
  volume={100 1},
  pages={
          59-68
        }
}
To evaluate innate effects of the trace elements zirconium, niobium, antimony and vanadium, and to reevaluate those of lead, 603 rats of the Long-Evans strain were fed a diet containing relatively small amounts of these elements in an environment reasonably free of trace contaminants. Groups of 100 or more divided as to sex were given 5 ppm (as metal) either zirconium, niobate, an tÂimoni te, or vanadyl ions, and 25 ppm lead (males only) in drinking water from the time of weaning until natural… 

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References

SHOWING 1-10 OF 15 REFERENCES

Zirconium, niobium, antimony and fluorine in mice: effects on growth, survival and tissue levels.

Inherent toxicity, manifest by decreased median life spans and longevity and by some suppression of growth of older animals, was observed in females given niobium and antimony, and zirconium occurred in both controls and experimental groups, and showed toxicity.

The Effect of Vanadium Pentoxide, Fluorides, and Tin Compounds on the Dental Caries Experience in Rats

  • J. Muhler
  • Chemistry
    Journal of dental research
  • 1957
In an attempt to learn the reason for this compound's apparent advantage in effectiveness over sodium fluoride, it was considered of interest to determine whether the form of the tin compound furnishing the stannous ion might contribute significantly to its superiority.

CHROMIUM, CADMIUM AND LEAD IN RATS: EFFECTS ON LIFE SPAN, TUMORS AND TISSUE LEVELS.

Serum cholesterol levels in rats fed thirteen trace elements.