Zipcodes and postage stamps: mRNA localisation signals and their trans-acting binding proteins.

@article{Chabanon2004ZipcodesAP,
  title={Zipcodes and postage stamps: mRNA localisation signals and their trans-acting binding proteins.},
  author={Herv{\'e} Chabanon and Ian Mickleburgh and John Christian Hesketh},
  journal={Briefings in functional genomics & proteomics},
  year={2004},
  volume={3 3},
  pages={240-56}
}
Messenger RNA (mRNA) localisation is a widespread mechanism within eukaryotic cells that provides local synthesis of proteins close to where they function. In general, this mRNA targeting involves the cytoskeleton and signals within the 3' untranslated region (3'UTR) of the transcript. In this paper, the authors review what is known of the nature of the localisation signals and the proteins that interact with them in animal cells. Specific examples are selected to illustrate the emerging… CONTINUE READING
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