Zinc uptake, oxidative stress and the FNR-like proteins of Lactococcus lactis.

@article{Scott2000ZincUO,
  title={Zinc uptake, oxidative stress and the FNR-like proteins of Lactococcus lactis.},
  author={Colin T. Scott and Helen Rawsthorne and Manisha Upadhyay and Claire A. Shearman and Michael J. Gasson and J. R. Guest and Jeffrey Green},
  journal={FEMS microbiology letters},
  year={2000},
  volume={192 1},
  pages={85-9}
}
Lactococcus lactis ssp. cremoris MG1363 contains two FNR homologues, FlpA and FlpB, encoded by the distal genes of two paralogous operons (orfX(A/B)-orfY(A/B)-flpA/B). An flpA flpB double mutant strain is hypersensitive to hydrogen peroxide and has a depleted intracellular Zn(II) pool. The phenotypes of the flp mutant strains suggest that FlpA and FlpB control the expression of high and low affinity ATP-dependent Zn(II) uptake systems, respectively. Plate tests revealed that expression from a… CONTINUE READING
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