Zinc transport and metallothionein secretion in the intestinal human cell line Caco-2.

@article{Moltedo2000ZincTA,
  title={Zinc transport and metallothionein secretion in the intestinal human cell line Caco-2.},
  author={Ornella Moltedo and Cinzia Verde and Alessandra Capasso and Elio Parisi and Paolo Remondelli and Stefano Bonatti and Xavier Alvarez-Hernandez and Jonathan Glass and Claudio Alvino and Arturo Leone},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 41},
  pages={31819-25}
}
Caco-2, a human cell line, displays several biochemical and morphological characteristics of differentiated enterocytes. Among these is the ability to transport zinc from the apical to the basal compartment. This process was enhanced following exposure by the apical compartment to increasing concentrations of the metal. High pressure liquid chromatography fractionation of the media obtained from cells labeled with radioactive zinc showed that metallothioneins (MTs), small metal-binding… CONTINUE READING

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