Zinc supplementation reduces blood ammonia and increases liver ornithine transcarbamylase activity in experimental cirrhosis

@article{Riggio1992ZincSR,
  title={Zinc supplementation reduces blood ammonia and increases liver ornithine transcarbamylase activity in experimental cirrhosis},
  author={Oliviero Riggio and Manuela Merli and Livio Capocaccia and Massimo Caschera and Angelo Zullo and Giorgio Pinto and Eugenio Gaudio and Antonio Franchitto and Roberta Spagnoli and Elvira D'aquilino and Siro Seri and R. Moretti and Alfredo Cantafora},
  journal={Hepatology},
  year={1992},
  volume={16}
}
Zinc deficiency is common in cirrhosis and may be involved in the alteration of ammonia metabolism. Rats with carbon tetrachloride–induced cirrhosis have high plasma ammonia and low serum and tissue zinc levels. We used this model to examine the effects of oral zinc supplementation on activities of plasma ammonia and liver ornithine transcarbamylase (a key enzyme in the urea cycle). These parameters were examined in two consecutive experiments. Each experiment included two groups of rats… 
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