Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study.

@article{Siwek2009ZincSA,
  title={Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study.},
  author={Marcin S Siwek and Dominika Dudek and Ian A. Paul and Magdalena Sowa-Ku{\'c}ma and Andrzej Zięba and Piotr Popik and Andrzej Pilc and Gabriel Nowak},
  journal={Journal of affective disorders},
  year={2009},
  volume={118 1-3},
  pages={187-95}
}
BACKGROUND One of the main problems in the therapy of depression is the limited efficacy of antidepressants and the limited utility of augmentation strategies. Zinc, a non competitive NMDA receptor antagonist exhibits preclinical antidepressant efficacy. Moreover, a preliminary clinical report suggests augmentation of antidepressant therapy by zinc in depression. METHODS A placebo-controlled, double blind study of zinc supplementation in imipramine therapy was conducted in sixty, 18-55-year… CONTINUE READING
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