Zinc stress induces copper depletion in Acinetobacter baumannii

  title={Zinc stress induces copper depletion in Acinetobacter baumannii},
  author={Karl A. Hassan and Victoria G. Pederick and Liam D. H. Elbourne and Ian T. Paulsen and James C Paton and Christopher A McDevitt and Bart A. Eijkelkamp},
  booktitle={BMC Microbiology},
The first row transition metal ions zinc and copper are essential to the survival of many organisms, although in excess these ions are associated with significant toxicity. Here, we examined the impact of zinc and copper stress on Acinetobacter baumannii, a common opportunistic pathogen. We show that extracellular zinc stress induces a copper-specific depletion phenotype in A. baumannii ATCC 17978. Supplementation with copper not only fails to rescue this phenotype, but further exacerbates the… CONTINUE READING