Zinc storage granules in the Malpighian tubules of Drosophila melanogaster

  title={Zinc storage granules in the Malpighian tubules of Drosophila melanogaster},
  author={Carlos Tejeda-Guzm{\'a}n and Maite A Castro and Thomas Kroll and Samuel M. Webb and Martha Barajas-Aceves and Beatriz Osorio and Fanis Missirlis},
Membrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for usage in protein cofactors, signaling, storage, or excretion. Here we identify zinc storage granules as the insect’s major zinc reservoir in primary Malpighian tubule epithelial cells of Drosophila melanogaster. The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C transporters is… CONTINUE READING
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