Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway.

@article{Kim2011ZincST,
  title={Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway.},
  author={Insook Kim and Eun Ji Park and Jeho Seo and Suk Jin Ko and Jinu Lee and Chul Hoon Kim},
  journal={Neuroreport},
  year={2011},
  volume={22 16},
  pages={839-44}
}
Hyperphosphorylated tau is a main component of neurofibrillary tangles, a pathological hallmark of Alzheimer's disease (AD). There is evidence that various protein kinases are involved in tau hyperphosphorylation. However, little is known about AD-related stimuli that activates tau kinases. We investigated the role of zinc, a metal involved in AD pathology, in tau phosphorylation. Zinc increased the phosphorylation of serine 214 (S214) in tau protein in human wild-type tau1-441-expressing SH… CONTINUE READING

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