Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.

@article{Haase2008ZincSA,
  title={Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.},
  author={Hajo Haase and Julia L Ober-Bl{\"o}baum and Gabriela Engelhardt and Silke Hebel and Antje Heit and Holger Heine and Lothar Rink},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={6491-502}
}
Cytosolic alterations of calcium ion concentrations are an integral part of signal transduction. Similar functions have been hypothesized for other metal ions, in particular zinc (Zn(2+)), but this still awaits experimental verification. Zn(2+) is important for multiple cellular functions, especially in the immune system. Among other effects, it influences formation and secretion of pro-inflammatory cytokines, including TNF-alpha. Here we demonstrate that these effects are due to a… CONTINUE READING