Zinc-secreting Paneth cells studied by ZP fluorescence.

  title={Zinc-secreting Paneth cells studied by ZP fluorescence.},
  author={Leonard J Giblin and Christopher J Chang and Anthony F Bentley and Cathleen J Frederickson and Stephen J Lippard and Christopher J. Frederickson},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  volume={54 3},
We have used a new family of zinc-specific-responsive fluorescent dyes (ZPs) to study the sequestration and secretion of zinc from Paneth cells, which are located in the bases of the crypts of Lieberkühn within the rat small intestine. Vivid ZP fluorescence zinc staining of Paneth cell secretory granules is seen in both cryostat sections and isolated crypts, providing firm evidence for a pool of labile (rapidly exchangeable) zinc within these cells. We further demonstrate that this ionic zinc… CONTINUE READING
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