Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters.

@article{MndezSnchez2001ZincSP,
  title={Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters.},
  author={Nah{\'u}m M{\'e}ndez-S{\'a}nchez and Ernesto Roldan-Valadez and Miguel A Flores and Ren{\'e} C{\'a}rdenas-V{\'a}zquez and Misael Uribe},
  journal={European journal of clinical investigation},
  year={2001},
  volume={31 9},
  pages={773-80}
}
BACKGROUND We have evidence for enterohepatic cycling of bilirubin experimentally and in vivo in humans. This study was designed to investigate whether Zn salts might inhibit such cycling of bilirubin. MATERIALS AND METHODS Micellar bile salt solutions with unconjugated bilirubin were prepared, appropriate concentrations of Zn salts were added, and unconjugated bilirubin precipitation was measured. Hamsters and Wistar rats were fed a chow diet or a chow diet enriched with 1% ZnSO4, and… CONTINUE READING