Zinc pyrithione induces apoptosis and increases expression of Bim

Abstract

We demonstrate herein that zinc pyrithione can induce apoptosis at nanomolar concentrations. Zinc pyrithione was a potent inducer of cell death causing greater than 40–60% apoptosis among murine thymocytes, murine splenic lymphocytes and human Ramos B and human Jurkat T cells. Conversely, the addition of a zinc chelator protected thymocytes against zinc… (More)
DOI: 10.1007/s10495-005-0811-9

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