Zinc protection against cadmium-induced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells

@article{Paksy2004ZincPA,
  title={Zinc protection against cadmium-induced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells},
  author={Katalin Paksy and Bertalan Varga and Peter Lazar},
  journal={Biometals},
  year={2004},
  volume={10},
  pages={27-36}
}
Adult female rats were treated subcutaneously (sc) with zinc chloride (ZnCl, 10 or 20 mg kg body weight, bw) four times during two ovarian cycles. The third injection was accompanied by cadmium chloride (CdCl) administration sc (2.5, 5 and 10 mg kg bw). The fourth zinc (Zn) treatment was followed by mating.ZnCl (20 mg kg) itself impaired fertility by 20%, while CdCl dose-dependently blocked the receptivity of female rats. In combination with 2.5 and 5 mg kg CdCl the metal salts decreased… 
Ovarian Toxicity Induced by Dietary Cadmium in Hen
TLDR
It is indicated that Cd exposure resulted in oxidative damage of hens' ovary tissue by altering antioxidant defense enzyme systems, lipid peroxidation, apoptosis and endocrine disturbance which may be possible underlying reproductive toxicity mechanisms induced by Cd.
Protective Effects of Selenium and Zinc Against Nickel Chloride-Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats.
TLDR
It is suggested that selenium and ZnCl2 ameliorated NiCl2-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant effects.
THE EFFECTS OF CADMIUM CHLORID ( CdCl2 ) ON THE FUNCTIONS OF REPRODUCTIVE SYSTEM OF THE MALE MICE
This study was designed to evaluate the effects of cadmium chloride (CdCl 2 ) on male reproductive system of Swiss albino mice. Forty male Swiss albino mice were divided randomly   in two groups (
Protective effects of selenium and zinc against potassium dichromate–induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats
TLDR
The co-treatment with Se or ZnCl2 has mitigated K2Cr2O7-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant and genoprotective effects, however, the combined co- treatment of both of them was less thyroprotective, and therefore, further investigations on the synergetic interaction of Se and Zn against CrVI toxicity using different doses and exposure routes are required.
Could vitamin C and zinc chloride protect the germ cells against sodium arsenite?
TLDR
Long-term As intake increased the proportions of abnormal sperm, whereas the concomitant intake of As with zinc or vitamin C enhanced the proportion of normal sperm, showing that such compounds could be used to protect this cell type against morphological defects.
Could zinc prevent reproductive alterations caused by cigarette smoke in male rats?
TLDR
Zinc, an antioxidant and stimulant of cell division, can be indicated as a promising treatment in men with infertility caused by the toxic components of cigarette smoke, showing a correlation between smoking and possible male infertility and subfertility.
Effects of Artichoke Extract Supplementation on Gonads of Cadmium-Treated Rats
TLDR
Artichoke extract exerted a clear protective effect against Cd-induced testicular damage and lowered NO production to the same level of that in the control groups.
Effect of simultaneous exposure to lead and cadmium on gonadotropin binding and steroidogenesis on granulosa cells: an in vitro study.
TLDR
It is suggested that both Pb and Cd can cause a reduction in LH and FSH binding, which significantly alters steroid production in vitro and exerts a direct influence on granulosa cell function.
Changes in some testicular biometric parameters and testicular function in cadmium chloride administered Wistar rats.
TLDR
The findings showed that Cadmium chloride has a deleterious effect on testicular function and biometric parameters of the testes may be important i n the assessment of testicularfunction.
...
1
2
3
...

References

SHOWING 1-10 OF 36 REFERENCES
Mitochondrial effects of low-level cadmium in rats: Interaction with zinc
TLDR
The treatment of rats by low level Cd gavage combined with zinc administration impairs the animals' health as shown by weight loss, and data suggest subcellular toxic effects due to treatment with low Cd doses as evidenced by the decrease in hepatic cytochrome c oxidase.
Toxic effects of cadmium on LHRH-induced LH release and ovulation in rats.
Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats.
Distribution of cadmium and its influence on the growth of offspring after an experimental application to female rabbits
TLDR
Interestingly relatively high concentrations of Cadmium in the ovaries and uterus were found in the experiments, and a significant decrease of weigh...
Zinc-induced tolerance to cadmium hepatotoxicity.
Cadmium-induced ovarian toxicity in hamsters, mice, and rats.
  • S. Rehm, M. Waalkes
  • Biology, Medicine
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1988
Specificity in Protection against Lethality and Testicular Toxicity from Cadmium∗
  • S. A. Gunn, T. C. Gould, W. Anderson
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1968
TLDR
It is illustrated that the organ most vulnerable to injury from cadmium, the testis, is the most resistant to protection, and selenium, zinc, and BAL are relatively more efficient in protecting against lethality than in preventing testicular injury from Cadmium.
...
1
2
3
4
...