Zinc prevents mitochondrial superoxide generation by inducing mitophagy in the setting of hypoxia/reoxygenation in cardiac cells.

@article{Bian2018ZincPM,
  title={Zinc prevents mitochondrial superoxide generation by inducing mitophagy in the setting of hypoxia/reoxygenation in cardiac cells.},
  author={Xiyun Bian and Tianming Teng and Huanhuan Zhao and Jiangyu Qin and Zhen Guo Qiao and Yuemin Sun and Zhiqiang Liun and Zhelong Xu},
  journal={Free radical research},
  year={2018},
  volume={52 1},
  pages={
          80-91
        }
}
Zinc plays a role in autophagy and protects cardiac cells from ischemia/reperfusion injury. This study aimed to test if zinc can induce mitophagy leading to attenuation of mitochondrial superoxide generation in the setting of hypoxia/reoxygenation (H/R) in cardiac cells. H9c2 cells were subjected to 4 h hypoxia followed by 2 h reoxygenation. Under normoxic… CONTINUE READING