Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats.

@article{Yan2012ZincON,
  title={Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats.},
  author={Guangyan Yan and Yina Huang and Q Lisa Bu and Lei Lv and Pengchi Deng and Jiaqing Zhou and Yanli Wang and Yanzhu Yang and Qiangqiang Liu and Xiaobo Cen and Ying-Lan Zhao},
  journal={Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering},
  year={2012},
  volume={47 4},
  pages={577-88}
}
Although zinc oxide nanoparticles (ZnO NPs) have been widely used, their potential hazards on mammalian and human remain largely unknown. In this study, the biochemical compositions of urine and kidney from the rats treated with ZnO NPs (100, 300 and 1000 mg/kg, respectively) were investigated using (1)H nuclear magnetic resonance (NMR) technique with the pattern recognition of partial least squares-discriminant analysis. Hematology, clinical biochemistry and kidney histopathological… CONTINUE READING
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