Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subtype specificity

  title={Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subtype specificity},
  author={A. Hosie and E. L. Dunne and R. J. Harvey and T. Smart},
  journal={Nature Neuroscience},
  • A. Hosie, E. L. Dunne, +1 author T. Smart
  • Published 2003
  • Biology, Medicine
  • Nature Neuroscience
  • Zinc ions are concentrated in the central nervous system and regulate GABAA receptors, which are pivotal mediators of inhibitory synaptic neurotransmission. Zinc ions inhibit GABAA receptor function by an allosteric mechanism that is critically dependent on the receptor subunit composition: αβ subunit combinations show the highest sensitivity, and αβγ isoforms are the least sensitive. Here we propose a mechanistic and structural basis for this inhibition and its dependence on the receptor… CONTINUE READING
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