Zinc-mediated dimerization and its effect on activity and conformation of staphylococcal enterotoxin type C.

@article{Chi2002ZincmediatedDA,
  title={Zinc-mediated dimerization and its effect on activity and conformation of staphylococcal enterotoxin type C.},
  author={Young-in Chi and Ingrid Sadler and Lynn M. Jablonski and Scott D Callantine and Claudia F. Deobald and Cynthia V Stauffacher and Gregory A. Bohach},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 25},
  pages={22839-46}
}
Staphylococcal enterotoxins are superantigen exotoxins that mediate food poisoning and toxic shock syndrome in humans. Despite their structural and functional similarities, superantigens display subtle differences in biological properties and modes of receptor binding as a result of zinc atoms bound differently in their crystal structures. For example, the crystal structures of the staphylococcal enterotoxins in the type C serogroup (SECs) contain a zinc atom coordinated by one aspartate and… CONTINUE READING