Zinc ions block the intracellular calcium release induced by caffeine in guinea-pig taenia caeci

@article{Nasu1995ZincIB,
  title={Zinc ions block the intracellular calcium release induced by caffeine in guinea-pig taenia caeci},
  author={Tetsuyuki Nasu},
  journal={Experientia},
  year={1995},
  volume={51},
  pages={113-116}
}
Zn2+ in low concentrations (0.005–0.1 mM) inhibited the transient contractions in response to caffeine (25 mM) in a dose-dependent manner in smooth muscle of intact guinea-pig taenia caeci. At Zn2+ concentrations higher than 0.1 mM, caffeine did not elicit any response. After saponin-treatment of the fibres, which leaves the Ca2+ storage sites intact, caffeine contraction was completely inhibited by Zn2+ at a relatively low concentration (0.03 mM). However, in Triton-X-100-treated fibres, in… CONTINUE READING

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