Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model.

@article{DabbaghBazarbachi2014ZincIA,
  title={Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model.},
  author={Husam Dabbagh-Bazarbachi and Gael Clergeaud and I. Quesada and M. Ortiz and C. O'Sullivan and J. Fern{\'a}ndez-Larrea},
  journal={Journal of agricultural and food chemistry},
  year={2014},
  volume={62 32},
  pages={
          8085-93
        }
}
Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc… Expand
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39 Citations

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