Zinc inhibits apoptosis upstream of ICE/CED-3 proteases rather than at the level of an endonuclease

@article{Wolf1997ZincIA,
  title={Zinc inhibits apoptosis upstream of ICE/CED-3 proteases rather than at the level of an endonuclease},
  author={Chad M Wolf and Salvatore J Morana and A. Eastman},
  journal={Cell Death and Differentiation},
  year={1997},
  volume={4},
  pages={125-129}
}
Apoptosis is commonly associated with DNA digestion, but it remains controversial as to which endonuclease is involved. The ability of zinc to inhibit DNA digestion in intact cells, and inhibit a Ca2+/Mg2+-dependent endonuclease in cell lysates, has been used frequently to suggest this is the endonuclease involved. However, zinc has many other effects on cells, and here it is shown that zinc also prevents many upstream events in apoptosis. These studies were performed in human ML-1 cells… CONTINUE READING

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