Zinc inhibition of cAMP signaling.

  title={Zinc inhibition of cAMP signaling.},
  author={Claudette Klein and Roger K Sunahara and Tracie Y. Hudson and Tomasz Heyduk and Allyn C. Howlett},
  journal={The Journal of biological chemistry},
  volume={277 14},
Zn(2+) is required as either a catalytic or structural component for a large number of enzymes and thus contributes to a variety of important biological processes. We report here that low micromolar concentrations of Zn(2+) inhibited hormone- or forskolin-stimulated cAMP production in N18TG2 neuroblastoma cells. Similarly, low concentrations inhibited hormone- and forskolin-stimulated adenylyl cyclase (AC) activity in membrane preparations and did so primarily by altering the V(max) of the… CONTINUE READING

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