Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity.

@article{Manzerra2001ZincIA,
  title={Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity.},
  author={Pat Manzerra and M Margarita Behrens and Lorella Maria Teresa Canzoniero and Xue Qing Wang and Valerie Heidinger and Tomomi Ichinose and Shan Ping Yu and Dennis W. Choi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 20},
  pages={11055-61}
}
Zinc is coreleased with glutamate from excitatory nerve terminals throughout the central nervous system and acutely inhibits N-methyl-d-aspartate (NMDA) receptor activation. Here we report that cultured murine cortical neurons briefly exposed to sublethal concentrations of zinc developed increased intracellular free Na(+), phosphorylation of Src kinase at tyrosine 220, and tyrosine phosphorylation of NMDA receptor 2A/2B subunits, in a fashion sensitive to the Src family kinase inhibitor 4-amino… CONTINUE READING

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