Zinc-induced suicidal erythrocyte death.

  title={Zinc-induced suicidal erythrocyte death.},
  author={Valentin Kiedaisch and Ahmad Akel and Olivier M. Niemoeller and Thomas Wieder and Florian Lang},
  journal={The American journal of clinical nutrition},
  volume={87 5},
BACKGROUND Zn(2+) stimulates secretory sphingomyelinase, which in turn produces ceramide, an important trigger of suicidal erythrocyte death or eryptosis. Eryptosis is characterized by exposure of phosphatidylserine (PS) at the erythrocyte surface and by cell shrinkage. As macrophages are equipped with PS receptors, they bind, engulf, and degrade PS-exposing cells. OBJECTIVE We examined whether Zn(2+) stimulates ceramide formation and PS exposure of erythrocytes and thus may be able to… CONTINUE READING