Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals.

@article{Kim1999ZincinducedCN,
  title={Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals.},
  author={Yong-hwan Kim and Eun Young Kim and Byoung Joo Gwag and Seonghyang Sohn and Jae Young Koh},
  journal={Neuroscience},
  year={1999},
  volume={89 1},
  pages={175-82}
}
Some studies have provided evidence that delayed death of hippocampal CA1 neurons in transient global ischemia occurs by classical apoptosis. Recently, translocation of synaptic zinc has been shown to play a key role in ischemic CA1 neuronal death. With these two lines of evidence, we examined in mouse cortical cultures the possibility that zinc neurotoxicity, slowly triggered over a day, may occur by classical apoptosis. Exposure of cortical cultures to 30-35 microM zinc for 24 h resulted in… CONTINUE READING

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