Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.

@article{Kang2011ZincFP,
  title={Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.},
  author={Ju-Gyeong Kang and Marcelo J Amar and Alan T Remaley and Jaeyul Kwon and Perry J. Blackshear and Ping-yuan Wang and Paul M. Hwang},
  journal={Journal of immunology},
  year={2011},
  volume={187 5},
  pages={2696-701}
}
Zinc finger protein tristetraprolin (TTP) modulates macrophage inflammatory activity by destabilizing cytokine mRNAs. In this study, through a screen of TTP-bound mRNAs in activated human macrophages, we have identified CCL3 mRNA as the most abundantly bound TTP target mRNA and have characterized this interaction via conserved AU-rich elements. Compared to the wild-type cells, TTP(-/-) macrophages produced higher levels of LPS-induced CCL3. In addition, the plasma level of CCL3 in TTP(-/-) mice… CONTINUE READING

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