Zinc finger protein sall2 is not essential for embryonic and kidney development.

  title={Zinc finger protein sall2 is not essential for embryonic and kidney development.},
  author={Akira Sato and Yuko Matsumoto and Urara Koide and Yuki Kataoka and Nobuaki Yoshida and Takashi Yokota and Makoto Asashima and Ryuichi Nishinakamura},
  journal={Molecular and cellular biology},
  volume={23 1},
SALL/Sall is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal), and heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We earlier reported that mice deficient in Sall1 die in the perinatal period and that kidney agenesis or severe dysgenesis are present. We have now generated mice lacking Sall2, another Sall family gene. Although Sall2 is expressed mostly in an overlapping fashion versus that of Sall1, Sall2-deficient mice show no apparent… CONTINUE READING

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