Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair.

@article{Liu2011ZincfingerP1,
  title={Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair.},
  author={Tong Ming Liu and Xi Guo and Hwee San Tan and James Hoi Po Hui and Bing Lim and Eng Hin Lee},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 9},
  pages={
          2711-20
        }
}
OBJECTIVE Human mesenchymal stem cells (hMSCs) represent one of the most promising stem cell therapies for traumatic injury and age-related degenerative diseases involving cartilage. However, few genetic factors regulating chondrogenesis of MSCs have been identified. One study showed that zinc-finger protein 145 (ZNF145), a transcription factor, was up-regulated during 3-lineage differentiation of hMSCs. The present study was undertaken to validate whether this novel transcription factor is… CONTINUE READING
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