Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells

@article{Lim2014ZincFA,
  title={Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells},
  author={Ji-Hong Lim},
  journal={BMB Reports},
  year={2014},
  volume={47},
  pages={405 - 410}
}
  • Ji-Hong Lim
  • Published 2014
  • Chemistry, Medicine
  • BMB Reports
ZBTB3 belongs to the Zinc finger and BTB/POZ domain containing transcription factor family; however, its biological role has rarely been studied. We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the ROS detoxification pathway. Suppression of ZBTB3 using two different short hairpin RNAs in human melanoma, lung carcinoma, and breast carcinoma results in diminished cell growth. In addition, we found that suppression… Expand
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