Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

@article{Pavletich1991ZincFR,
  title={Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A},
  author={N. P. Pavletich and C. O. Pabo},
  journal={Science},
  year={1991},
  volume={252},
  pages={809 - 817}
}
The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene expression. The crystal structure of a complex containing the three zinc fingers from Zif268 (a mouse immediate early protein) and a consensus DNA-binding site has been determined at 2.1 angstroms resolution and refined to a crystallographic R factor of 18.2 percent. In this complex, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix. Each finger has a similar… Expand
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