Zinc downmodulates thf GABAc receptor current in cone horizontal cells acutely isolated from the catfish retina.

@article{Dong1995ZincDT,
  title={Zinc downmodulates thf GABAc receptor current in cone horizontal cells acutely isolated from the catfish retina.},
  author={Cora Dong and Frank S. Werblin},
  journal={Journal of neurophysiology},
  year={1995},
  volume={73 2},
  pages={916-9}
}
1. We studied the effect of zinc on the gamma-aminobutyric acid-C (GABAC) receptor in acutely isolated catfish cone horizontal cells using the whole cell patch-clamp technique. 2. GABA activates the GABAC receptor with a half-activation concentration (EC50) of 2.99 microM. The Hill coefficient is 1.32. Desensitization of the receptor is evident when GABA concentration is > 3 microM. 3. Zinc downmodulates the GABAc receptor current, elicited by 30 microM GABA, with a half-inhibition… CONTINUE READING