Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa.

@article{Obolensky2011ZincdesferrioxamineAR,
  title={Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa.},
  author={Alexey Obolensky and Eduard Berenshtein and Michal Lederman and Baruch Bulvik and Ruslana Alper-Pinus and Ruth Yaul and Efrat Deleon and Itay Chowers and Mordechai Mottie Chevion and Eyal Banin},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 8},
  pages={1482-91}
}
Iron-associated oxidative injury plays a role in retinal degeneration such as age-related macular degeneration and retinitis pigmentosa. The metallo-complex zinc-desferrioxamine (Zn/DFO) may ameliorate such injury by chelation of labile iron in combination with release of zinc. We explored whether Zn/DFO can affect the course of retinal degeneration in the rd10 mouse model of retinitis pigmentosa. Zn/DFO-treated animals showed significantly higher electroretinographic responses at 3 and 4.5… CONTINUE READING

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